Building unconventional G protein-coupled receptors, one block at a time.
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ABSTRACT: The structure, function, and dynamics of canonical activation of heterotrimeric G proteins by the seven-transmembrane G protein-coupled receptors (GPCRs) have been illustrated in detail. However, emerging studies during the past decade have started to shed light on how the same G proteins may also be accessed and modulated by a diverse family of receptors that are not conventional GPCRs. Can we learn about common themes and variations in how cells assemble these atypical GPCRs?
SUBMITTER: Ghosh P
PROVIDER: S-EPMC8779748 | biostudies-literature |
REPOSITORIES: biostudies-literature
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