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A Double-Site Chemodosimeter for Selective Fluorescence Detection of a Nerve Agent Mimic.

ABSTRACT: A novel two-site chemodosimeter (SWJT-4) based on fluorescein skeleton to detect diethyl chlorophosphate (DCP) was designed and synthesized. It is a turn-on fluorescent probe for DCP with good selectivity and obvious color change in aqueous solution. Interestingly, the two oxime groups of SWJT-4 as dual response sites initiated different reactions with DCP to form a cyano group and an isoxazole ring, respectively. The corresponding mechanism was confirmed by ¹H NMR, MS and DFT calculation. Moreover, SWJT-4 could be used as a fluorescent test paper to detect DCP vapor.

SUBMITTER: Guo X

PROVIDER: S-EPMC8780492 | biostudies-literature |

REPOSITORIES: biostudies-literature

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