Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed MM
PROVIDER: S-EPMC8781562 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Viruses 20211230 1
Merkel cell polyomavirus (MCV) is the causative agent for the majority of Merkel cell carcinoma (MCC) cases. Polyomavirus-associated MCC (MCCP) is characterized by the integration of MCV DNA into the tumor genome and a low tumor mutational burden. In contrast, nonviral MCC (MCCN) is characterized by a high tumor mutational burden induced by UV damage. Since the discovery of MCV, much work in the field has focused on understanding the molecular mechanisms of oncogenesis driven by the MCV tumor (T ...[more]