A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is the second-leading cause of cancer-related mortality in the United States and a leading cause of cancer-related mortality worldwide. Loss of SMAD4, a critical tumor suppressor and the central node of the transforming growth factor-beta superfamily, is associated with worse outcomes for colorectal cancer patients; however, it is unknown whether an RNA-based profile associated with SMAD4 expression could be used to better identify high-risk colorectal cancer patients.

Aim

Identify a gene expression-based SMAD4-modulated profile and test its association with patient outcome.

Methods and results

Using a discovery dataset of 250 colorectal cancer patients, we analyzed expression of BMP/Wnt target genes for association with SMAD4 expression.

SUBMITTER: Szeglin BC 

PROVIDER: S-EPMC8789617 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature