Increased ventral striatal functional connectivity in patients with schizophrenia during reward anticipation.

ABSTRACT:

Background

Growing evidence points towards dysfunction of the ventral striatum as a neural substrate of motivational impairments in schizophrenia. Ventral striatal activity during reward anticipation is generally reduced in patients with schizophrenia and specifically correlates with apathy. However, little is known about the cortico-striatal functional connectivity in patients with schizophrenia during reward anticipation and its relation to negative symptoms.

Objectives

The aim of this study was to identify categorical group differences in ventral striatal functional connectivity during reward anticipation between patients with schizophrenia and healthy controls, and dimensional associations between cortico-striatal functional connectivity and negative symptom severity.

SUBMITTER: Carruzzo F 

PROVIDER: S-EPMC8789684 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature