Fatal Pneumonia Associated With a Novel Genotype of Human Coronavirus OC43.

ABSTRACT: Since its first discovery in 1967, human coronavirus OC43 (HCoV-OC43) has been associated with mild self-limiting upper respiratory infections worldwide. Fatal primary pneumonia due to HCoV-OC43 is not frequently described. This study describes a case of fatal primary pneumonia associated with HCoV-OC43 in a 75-year-old patient with good past health. The viral loads of the respiratory tract specimens (bronchoalveolar lavage and endotracheal aspirate) from diagnosis to death were persistently high (3.49 × 10⁶-1.10 × 10¹⁰ copies/ml). HCoV-OC43 at a 6.46 × 10³ copies/ml level was also detected from his pleural fluid 2 days before his death. Complete genome sequencing and phylogenetic analysis showed that the present HCoV-OC43 forms a distinct cluster with thre

SUBMITTER: Lau SKP 

PROVIDER: S-EPMC8795699 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature