Dataset Information
Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus.
Ontology highlight
ABSTRACT: Methods
A total of 160 volunteers were studied: 108 with T2DM and 52 participants as control, who served as the control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the genomic region of TNF-α- 308G/A and LEPR Gln223Arg were carried out.Results
The frequency of LEPR Gln223Arg genotypes in T2DM and control groups showed significant differences in the distribution of genotypes (p < 0.05). The frequency also of TNF-α- 308G/A genotypes in T2DM and control subjects showed significant differences in the distribution of genotypes (p < 0.05).Conclusion
Our results indicate that there are significant differences in the distribution of genotypes and alleles between the individuals with T2DM and control subjects (p < 0.05).
SUBMITTER: Trapali M
PROVIDER: S-EPMC8796026 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Association of <i>TNF</i>-α 308G/A and <i>LEPR</i> Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus.
Genes 20211227 1
The objective of the present study was to identify the association of the <i>TNF</i>-α- 308G/A and leptin receptor (<i>LEPR</i>) Gln223Arg polymorphisms with the risk of development of type 2 diabetes mellitus (T2DM).<h4>Methods</h4>A total of 160 volunteers were studied: 108 with T2DM and 52 participants as control, who served as the control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the genomic region of <i>TNF</i>-α- 308G/A and <i>LEPR</i> Gln223A ...[more]