Transcription factor specificity limits the number of DNA-binding motifs.
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ABSTRACT:
SUBMITTER: Aptekmann AA
PROVIDER: S-EPMC8797260 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Transcription factor specificity limits the number of DNA-binding motifs.
Aptekmann Ariel A AA Bulavka Denys D Nadra Alejandro D AD Sánchez Ignacio E IE
PloS one 20220128 1
We study the limits imposed by transcription factor specificity on the maximum number of binding motifs that can coexist in a gene regulatory network, using the SwissRegulon Fantom5 collection of 684 human transcription factor binding sites as a model. We describe transcription factor specificity using regular expressions and find that most human transcription factor binding site motifs are separated in sequence space by one to three motif-discriminating positions. We apply theorems based on the ...[more]
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