Dataset Information

Association between insulin-like growth factor 1 gene rs5742612 polymorphism and malignant tumor susceptibility: a meta-analysis

ABSTRACT:

Background

Malignant tumor is a serious threat to human health and life, which is a difficult problem in the world. Insulin-like growth factor 1 (IGF1) is an important mitotic factor in vivo. It usually acts in the way of autocrine and paracrine to control the proliferation, differentiation, and apoptosis of various cells, IGF1 has a strong mitotic and anti-apoptosis activity in malignant cells. Single nucleotide polymorphism (SNP) is an important part of individual genetic variation. A large number of studies have shown that IGF1 SNP associated with the risk of a malignant tumor may be an important biomarker for the diagnosis of malignant tumors. Therefore, the article will investigate the association between rs5742612 polymorphism of IGF1 gene and malignant tumor susceptibility.

Methods

We searched for studies in five databases (PubMed, Embase, Web of Science, CNKI and Wanfang) regarding the association between IGF1 gene rs5742612 and malignant tumor susceptibility. Odds ratios (ORs) and the related 95% confidence intervals (CIs) were employed to assess the strength of the associations.

Results

Ultimately this study identified seven articles that met the inclusion criteria, involving 2,581 cases and 2,445 controls. There was no significant correlation between IGF1 gene rs5742612 polymorphism and malignant tumor susceptibility [thymidine (T) vs. cytimidine (C), OR =0.99, 95% CI: 0.85–1.15, P=0.91; TC vs. CC: OR =1.03, 95% CI: 0.81–1.32, P=0.79; TT vs. CC: OR =0.92, 95% CI: 0.73–1.17, P=0.52; TT + TC =0.91; TC vs. CC: OR =0.97, 95% CI: 0.77–1.22, P=0.80; TT vs. TC + CC: OR =0.98, 95% CI: 0.81–1.18, P=0.83].

Conclusions

There was no significant association detected between IGF1 gene rs5742612 polymorphism and malignant tumor susceptibility.

SUBMITTER: Zhou X

PROVIDER: S-EPMC8797683 | biostudies-literature |

REPOSITORIES: biostudies-literature

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