Dataset Information

The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis.

ABSTRACT: Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for degrading essentially all components of the extracellular matrix (ECM). Accumulating evidence suggests that MMPs might play a critical role in growth, invasion, and metastasis of malignant tumors. A single nucleotide polymorphism (SNP) in the promoter region of MMP-12, MMP-12 82 A/G (rs2276109), has been recognized to play a critical role in regulating the expression of MMP-12, however, its correlation with tumor susceptibility remains controversial. To address this issue, we performed meta-analysis to investigate the association MMP-12 82 A/G polymorphism and susceptibility of nine malignant tumors from 11 studies, including 6153 cancer patients and 6838 controls. Two reviewers independently screened studies for eligibility and extracted data for included studies. While overall no evident association between MMP-12 82 A/G and tumor susceptibility was observed, subgroup analysis revealed a specific role of G allele in increasing the susceptibility for epithelial ovarian carcinoma (EOC) using the allele model (fixed effects OR = 2.45, 95% CI = 1.46-4.10, P = 0.001) and the dominant model (fixed effects OR = 2.52, 95% CI = 1.49-4.24, P = 0.001). We thus suggest that G allele of MMP-12 82 A/G polymorphism is a genetic risk factor for EOC.

SUBMITTER: Chen SS

PROVIDER: S-EPMC4565261 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis.

Chen Sheng-Song SS Song Juan J Tu Xiao-Yun XY Zhao Ji-Hua JH Ye Xiao-Qun XQ

International journal of clinical and experimental medicine 20150715 7

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for degrading essentially all components of the extracellular matrix (ECM). Accumulating evidence suggests that MMPs might play a critical role in growth, invasion, and metastasis of malignant tumors. A single nucleotide polymorphism (SNP) in the promoter region of MMP-12, MMP-12 82 A/G (rs2276109), has been recognized to play a critical role in regulating the expression of MMP-12, however, its correlation ...[more]

PMID: 26379878

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Dataset Information

The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis.

Publications

The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis.

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