Dataset Information

Resveratrol affects the migration and apoptosis of monocytes by blocking HMGB1/NF-κB pathway.

ABSTRACT:

Background

Chronic inflammation is now recognized as a causal factor of aging. Resveratrol is a non-flavonoid compound that widely exists in plant species, exerting anti-inflammatory effects in vitro and in animal models. The chemotaxis of inflammatory cells and secretion of cytokines are key characters in inflammation response.

Methods

The effects of lipopolysaccharide (LPS) and high mobility group box-1 (HMGB1) chromosomal on the migration, inflammatory response, and apoptosis of monocytes were detected. THP-1 cells were used to study the effects of resveratrol treatment on LPS- and HMGB-induced monocytes. We aimed to investigate the effect of Resveratrol on monocyte migration and the expression of a special cytokine named HMGB1 in THP-1 cells.

Results

Resveratrol obviously inhibited THP-1 migration induced by LPS. LPS increased the expression of HMGB1 and its release in THP-1 cells, which were both decreased by resveratrol. Resveratrol inhibited the activity of NF-κB-p65 and the translocation of NF-κB-p65 from nucleus to cytoplasm induced by LPS. In addition, Resveratrol increased LPS and HMGB1-inhibited monocyte apoptosis. Resveratrol inhibited the LPS-induced HMGB1 secretion and its activation through NF-κB pathway. The THP-1 migration induced by LPS was inhibited by resveratrol.

Conclusions

Resveratrol may inhibit monocyte migration and induce apoptosis by blocking downstream HMGB1/NF-κB/MCP-1 signaling pathways, thereby reducing systemic inflammation.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC8797930 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

Resveratrol affects the migration and apoptosis of monocytes by blocking HMGB1/NF-κB pathway.

Zhang Yuwei Y Dong Qiaoliang Q Liu Chan C Zhu Yingfei Y Qin Xueli X Qi Zihan Z Zhang Xi X Guo Hongmei H Li Weixiang W Liu Meng M Gan Lin L Liu Hong H

Translational cancer research 20210801 8

<h4>Background</h4>Chronic inflammation is now recognized as a causal factor of aging. Resveratrol is a non-flavonoid compound that widely exists in plant species, exerting anti-inflammatory effects in vitro and in animal models. The chemotaxis of inflammatory cells and secretion of cytokines are key characters in inflammation response.<h4>Methods</h4>The effects of lipopolysaccharide (LPS) and high mobility group box-1 (HMGB1) chromosomal on the migration, inflammatory response, and apoptosis o ...[more]

PMID: 35116666

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Dataset Information

Resveratrol affects the migration and apoptosis of monocytes by blocking HMGB1/NF-κB pathway.

Background

Methods

Results

Conclusions

Publications

Resveratrol affects the migration and apoptosis of monocytes by blocking HMGB1/NF-κB pathway.

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