GLUT1/3/4 as novel biomarkers for the prognosis of human breast cancer.

ABSTRACT:

Background

Anomalous expression of glucose transporters (GLUTs) has been observed in a variety of tumor tissues. Although GLUT factors have been shown to have prognostic value for some cancer types, detailed bioinformatics investigation of the factors contributing to the prognostic prediction for patients with breast cancer (BC) has not yet been performed.

Methods

In this study, we examined the transcription levels of GLUT1, GLUT3, and GLUT4 and their associations with prognostic clinical data in patients with BC from the ONCOMINE database, using gene expression profiling interactive analysis (GEPIA), Kaplan-Meier (KM) plotter, and cBioPortal online tools.

Results

The transcription level of GLUT1 was significantly higher in the BC samples t

SUBMITTER: Zeng K 

PROVIDER: S-EPMC8797933 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature