Synaptic memory requires CaMKII.
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ABSTRACT:
SUBMITTER: Tao W
PROVIDER: S-EPMC8798046 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Synaptic memory requires CaMKII.
Tao Wucheng W Lee Joel J Chen Xiumin X Díaz-Alonso Javier J Zhou Jing J Pleasure Samuel S Nicoll Roger A RA
eLife 20211215
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP ('learning') are well understood, the maintenance of LTP ('memory') has remained contentious over the last 20 years. Here, we find that Ca<sup>2+</sup>-calmodulin-dependent kinase II (CaMKII) contributes to synaptic transmission and is required LTP maintenance. Acute inhibition of CaMKII erases LTP and transient inhibition of CaMKII enhances su ...[more]
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