Dataset Information

Associations between polymorphisms in genes of base excision repair pathway and lung cancer risk

ABSTRACT:

Background

The correlation between at-risk polymorphisms in genes of base excision repair (BER) pathways and lung cancer (LC) risk was newly considered but still not clear, a systematic review and updated meta-analysis was performed in the current study.

Methods

We identified and recorded the eligible publications from Google Scholar, PubMed, Medicine and Web of Science. For all calculates, odds ratios (ORs) and 95% confidence intervals (CIs) were applied to estimate the potential relationship between these genetic variants and LC risk. Subsequently, Begg’s funnel plot and Egger’s test were used to appraising the publication bias.

Results

A total of 202 case-control studies extracted from 116 publications were enrolled. Firstly, we analyzed six polymorphisms in XRCC1, the overall analysis results of homozygote and recessive models illustrated that rs3213245 polymorphism was remarkably linked to an upgrade LC risk. Then, in the subgroup analysis stratified by ethnicity, we uncovered a meaningfully raised risk of LC in Asian population in homozygote and recessive models for rs3213245 polymorphism, as well as in the allelic contrast, heterozygous and dominant models for rs915927 polymorphism. For APEX1-rs1760944 polymorphism, the overall analysis suggested a significantly decreased risk. Another gene was OGG1, we identified a significantly upregulated risk in recessive model of OGG1-rs1052133 polymorphism for LC.

Conclusions

XRCC1-rs3213245 and OGG1-rs1052133 polymorphisms are risk factors for LC, while APEX1-rs1760944 polymorphism is a protective factor.

SUBMITTER: Liu S

PROVIDER: S-EPMC8799111 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BACKGROUND:Previous research indicates increased prostate cancer risk for pesticide applicators and pesticide manufacturing workers. Although underlying mechanisms are unknown, evidence suggests a role of oxidative DNA damage. OBJECTIVES:Because base excision repair (BER) is the predominant pathway involved in repairing oxidative damage, we evaluated interactions between 39 pesticides and 394 tag single-nucleotide polymorphisms (SNPs) for 31 BER genes among 776 prostate cancer cases and 1,444 male controls in a nested case-control study of white Agricultural Health Study (AHS) pesticide applicators. METHODS:We used likelihood ratio tests from logistic regression models to determine p-values for interactions between three-level pesticide exposure variables (none/low/high) and SNPs (assuming a dominant model), and the false discovery rate (FDR) multiple comparison adjustment approach. RESULTS:The interaction between fonofos and rs1983132 in NEIL3 [nei endonuclease VIII-like 3 (Escherichia coli)], which encodes a glycosylase that can initiate BER, was the most significant overall [interaction p-value (pinteract) = 9.3 × 10-6; FDR-adjusted p-value = 0.01]. Fonofos exposure was associated with a monotonic increase in prostate cancer risk among men with CT/TT genotypes for rs1983132 [odds ratios (95% confidence intervals) for low and high use compared with no use were 1.65 (0.91, 3.01) and 3.25 (1.78, 5.92), respectively], whereas fonofos was not associated with prostate cancer risk among men with the CC genotype. Carbofuran and S-ethyl dipropylthiocarbamate (EPTC) interacted similarly with rs1983132; however, these interactions did not meet an FDR < 0.2. CONCLUSIONS:Our significant finding regarding fonofos is consistent with previous AHS findings of increased prostate cancer risk with fonofos exposure among those with a family history of prostate cancer. Although requiring replication, our findings suggest a role of BER genetic variation in pesticide-associated prostate cancer risk.