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Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer.

ABSTRACT: Estrogen receptor (ER) and progesterone receptor (PR) are important prognostic and predictive biomarkers in breast cancer. PET using ER- and PR-specific radioligands enables a whole-body, noninvasive assessment of receptor expression. Recent investigations of ER imaging with ¹⁸F-fluoroestradiol have focused on diagnosing ER-positive metastatic disease, optimizing ER-targeted drug dosage, and predicting endocrine therapy benefit. Studies of PR imaging with ¹⁸F-fluorofuranyl norprogesterone have investigated how imaging changes in PR expression as a downstream target of ER activation may reflect an early response to ER-targeted therapy. This focused review highlights recent achievements in preclinical and clinical imaging of ER and PR in breast cancer.

SUBMITTER: Kumar M

PROVIDER: S-EPMC8801958 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer.

Kumar Manoj M Salem Kelley K Tevaarwerk Amye J AJ Strigel Roberta M RM Fowler Amy M AM

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20191115 2

Estrogen receptor (ER) and progesterone receptor (PR) are important prognostic and predictive biomarkers in breast cancer. PET using ER- and PR-specific radioligands enables a whole-body, noninvasive assessment of receptor expression. Recent investigations of ER imaging with <sup>18</sup>F-fluoroestradiol have focused on diagnosing ER-positive metastatic disease, optimizing ER-targeted drug dosage, and predicting endocrine therapy benefit. Studies of PR imaging with <sup>18</sup>F-fluorofuranyl ...[more]

PMID: 31732674

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