Unknown

Dataset Information

0

Pharmacokinetics of Ginsenoside Rb1, Rg3, Rk1, Rg5, F2, and Compound K from Red Ginseng Extract in Healthy Korean Volunteers.


ABSTRACT: Individual differences in ginsenoside pharmacokinetics following ginseng administration in humans are still unclear. We aimed to investigate the pharmacokinetic properties of various ginsenosides, including Rb1, Rg3, Rg5, Rk1, F2, and compound K (CK), after a single oral administration of red ginseng (RG) and bioconverted red ginseng extract (BRG). This was a randomized, open-label, single-dose, single-sequence crossover study with washout every 1 week, and 14 healthy Korean men were enrolled. All subjects were equally assigned to two groups and given RG or BRG capsules. The pharmacokinetic parameters of ginsenosides were measured from the plasma drug concentration-time curve of individual subjects. Ginsenosides Rg3, Rk1 + Rg5, F2, and CK in the BRG group showed a higher C max, AUC(0-t), and AUC(0-∞) and shorter T max (for CK) than those in the RG group. These results suggest that BRG may lead to a higher absorption rate of bioactive ginsenosides. This study provides valuable information on the pharmacokinetics of various bioactive ginsenosides, which is needed to enhance the therapeutic efficacy and pharmacological activity of ginseng.

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC8803428 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pharmacokinetics of Ginsenoside Rb1, Rg3, Rk1, Rg5, F2, and Compound K from Red Ginseng Extract in Healthy Korean Volunteers.

Kim Hyung Joong HJ   Oh Tae Kyu TK   Kim Yoon Hee YH   Lee Jaesun J   Moon Joo Myung JM   Park Yong Sun YS   Sung Chang Min CM  

Evidence-based complementary and alternative medicine : eCAM 20220124


Individual differences in ginsenoside pharmacokinetics following ginseng administration in humans are still unclear. We aimed to investigate the pharmacokinetic properties of various ginsenosides, including Rb1, Rg3, Rg5, Rk1, F2, and compound K (CK), after a single oral administration of red ginseng (RG) and bioconverted red ginseng extract (BRG). This was a randomized, open-label, single-dose, single-sequence crossover study with washout every 1 week, and 14 healthy Korean men were enrolled. A  ...[more]

Similar Datasets

| S-EPMC3659545 | biostudies-literature
| S-EPMC8271777 | biostudies-literature
| S-EPMC5695252 | biostudies-literature
| S-EPMC8537973 | biostudies-literature
| S-EPMC2677725 | biostudies-literature
| S-EPMC8540751 | biostudies-literature
| S-EPMC3349346 | biostudies-literature
| S-EPMC6187048 | biostudies-literature
| S-EPMC5686332 | biostudies-literature
| S-EPMC11387729 | biostudies-literature