Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC8810981 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Liu Zhicheng Z Chen Chuangqi C Yan Mei M Zeng Xiangtai X Zhang Yuchao Y Lai Dongming D
Discover oncology 20220203 1
Colorectal cancer (CRC) is considered to be a leading cause of cancer-related death. Centromere protein O (CENPO) can prevent the separation of sister chromatids and cell death after spindle injury. Nevertheless, the role of CENPO in CRC has not been reported. The expression level of CENPO in CRC was revealed by TCGA database and immunohistochemical (IHC) staining. Subsequently, the loss-of-function assays were performed to identified the role of CENPO in CRC in vitro and in vivo. Our data demon ...[more]