Ontology highlight
ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC8815314 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Tang Juan J Xiao Yizhi Y Lin Guoxin G Guo Hui H Deng Han-Xiang HX Tu Sha S Langdon Wallace Y WY Yang Huixiang H Tao Lijian L Li Yalan Y Pope R Marshall RM Gupta Neetu N Zhang Jian J
Science signaling 20211026 706
In response to microbes and other danger signals, the NLRP3 inflammasome in immune cells triggers the activation of the protease caspase-1, which mediates the maturation of the inflammatory cytokine IL-1β. Here, we investigated how the NLRP3 inflammasome is regulated. We found that its activation in primary mouse macrophages induced the Src family kinase Lyn to phosphorylate NLRP3 at Tyr<sup>918</sup>, which correlated with a subsequent increase in its ubiquitination that facilitated its proteas ...[more]