Ontology highlight
ABSTRACT:
SUBMITTER: Arhontoulis DC
PROVIDER: S-EPMC8820666 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20220201
Acute cardiac injuries occur in 20-25% of hospitalized COVID-19 patients. Despite urgent needs, there is a lack of 3D organotypic models of COVID-19 hearts for mechanistic studies and drug testing. Herein, we demonstrate that human cardiac organoids (hCOs) are a viable platform to model the cardiac injuries caused by COVID-19 hyperinflammation. As IL-1βis an upstream cytokine and a core COVID-19 signature cytokine, it was used to stimulate hCOs to induce the release of a milieu of proinflammator ...[more]