Age-Related Increase in Lactate Dehydrogenase Activity in Skeletal Muscle Reduces Life Span in Drosophila.
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SUBMITTER: Hunt LC
PROVIDER: S-EPMC8824701 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
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Age-Related Increase in Lactate Dehydrogenase Activity in Skeletal Muscle Reduces Life Span in Drosophila.
Hunt Liam C LC Demontis Fabio F
The journals of gerontology. Series A, Biological sciences and medical sciences 20220201 2
Metabolic adaptations occur with aging but the significance and causal roles of such changes are only partially known. In Drosophila, we find that skeletal muscle aging is paradoxically characterized by increased readouts of glycolysis (lactate, NADH/NAD+) but reduced expression of most glycolytic enzymes. This conundrum is explained by lactate dehydrogenase (LDH), an enzyme necessary for anaerobic glycolysis and whose expression increases with aging. Experimental Ldh overexpression in skeletal ...[more]
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