Synthesis of aromatic lactone analogues of Lipoxin A4.
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ABSTRACT: Objective
Synthesis of novel aromatic Lipoxin A4 lactone analogues.Results
Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12-13% yields, employing 2-deoxy-D-ribose as a chiral pool starting material and the classical E-selective Wittig olefination.
SUBMITTER: Ismael A
PROVIDER: S-EPMC8827294 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Synthesis of aromatic lactone analogues of Lipoxin A4.
Ismael Aya A Zeeshan Muhammad M Hansen Jørn H JH
BMC research notes 20220209 1
<h4>Objective</h4>Synthesis of novel aromatic Lipoxin A4 lactone analogues.<h4>Results</h4>Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12-13% yields, employing 2-deoxy-D-ribose as a chiral pool starting material and the classical E-selective Wittig olefination. ...[more]
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