Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC8827659 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Li Jun J Lu Hengyu H Ng Patrick Kwok-Shing PK Pantazi Angeliki A Ip Carman Ka Man CKM Jeong Kang Jin KJ Amador Bianca B Tran Richard R Tsang Yiu Huen YH Yang Lixing L Song Xingzhi X Dogruluk Turgut T Ren Xiaojia X Hadjipanayis Angela A Bristow Christopher A CA Lee Semin S Kucherlapati Melanie M Parfenov Michael M Tang Jiabin J Seth Sahil S Mahadeshwar Harshad S HS Mojumdar Kamalika K Zeng Dong D Zhang Jianhua J Protopopov Alexei A Seidman Jonathan G JG Creighton Chad J CJ Lu Yiling Y Sahni Nidhi N Shaw Kenna R KR Meric-Bernstam Funda F Futreal Andrew A Chin Lynda L Scott Kenneth L KL Kucherlapati Raju R Mills Gordon B GB Liang Han H
Science advances 20220209 6
Fusion genes represent a class of attractive therapeutic targets. Thousands of fusion genes have been identified in patients with cancer, but the functional consequences and therapeutic implications of most of these remain largely unknown. Here, we develop a functional genomic approach that consists of efficient fusion reconstruction and sensitive cell viability and drug response assays. Applying this approach, we characterize ~100 fusion genes detected in patient samples of The Cancer Genome At ...[more]