Proteomics

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Molecular and functional landscape of malignant serous effusions for precision oncology


ABSTRACT: Personalized treatment for patients with advanced solid tumors critically depends on the deep characterization of tumor cells from patient biopsies. Here, we comprehensively characterize a pan-cancer cohort of 150 malignant serous effusion (MSE) samples at the cellular, molecular, and functional level. We find that MSE-derived cancer cells retain the genomic and transcriptomic profiles of their corresponding primary tumors, validating their use as a patient-relevant model system for solid tumor biology. Integrative analyses reveal that baseline gene expression patterns relate to global ex vivo drug sensitivity, while high-throughput drug-induced transcriptional changes in MSE samples are indicative of drug mode of action and acquired treatment resistance. A case study exemplifies the added value of multi-modal MSE profiling for patients who lack genetically stratified treatment options. In summary, our study provides a functional multi-omics view on a pan-cancer solid tumor cohort and underlines the feasibility and utility of MSE-based precision oncology.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ascites

DISEASE(S): Breast Cancer

SUBMITTER: Valentina Cappelletti  

LAB HEAD: Paola Picotti

PROVIDER: PXD052582 | Pride | 2024-10-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20052024_PE03_Trp_Report.tsv Tabular
230315_LU02_fehra_PE03_55.raw Raw
230315_LU02_fehra_PE03_56_20230320183444.raw Raw
230315_LU02_fehra_PE03_57.raw Raw
230315_LU02_fehra_PE03_58.raw Raw
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