Ontology highlight
ABSTRACT:
SUBMITTER: Liffner B
PROVIDER: S-EPMC8828742 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Liffner Benjamin B Balbin Juan Miguel JM Shami Gerald J GJ Siddiqui Ghizal G Strauss Jan J Frölich Sonja S Heinemann Gary K GK Edwards Ella May EM Alder Arne A Wichers Jan Stephan JS Creek Darren J DJ Tilley Leann L Dixon Matthew W A MWA Gilberger Tim-Wolf TW Wilson Danny W DW
Communications biology 20220209 1
Merozoite invasion of host red blood cells (RBCs) is essential for survival of the human malaria parasite Plasmodium falciparum. Proteins involved with RBC binding and invasion are secreted from dual-club shaped organelles at the apical tip of the merozoite called the rhoptries. Here we characterise P. falciparum Cytosolically Exposed Rhoptry Leaflet Interacting protein 2 (PfCERLI2), as a rhoptry bulb protein that is essential for merozoite invasion. Phylogenetic analyses show that cerli2 arose ...[more]