Semaphorins as Potential Immune Therapeutic Targets for Cancer.
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ABSTRACT:
SUBMITTER: Jiang J
PROVIDER: S-EPMC8830438 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Semaphorins as Potential Immune Therapeutic Targets for Cancer.
Jiang Jun J Zhang Fang F Wan Yi Y Fang Ke K Yan Ze-Dong ZD Ren Xin-Ling XL Zhang Rui R
Frontiers in oncology 20220127
Semaphorins are a large class of secreted or membrane-bound molecules. It has been reported that semaphorins play important roles in regulating several hallmarks of cancer, including angiogenesis, metastasis, and immune evasion. Semaphorins and their receptors are widely expressed on tumor cells and immune cells. However, the biological role of semaphorins in tumor immune microenvironment is intricate. The dysregulation of semaphorins influences the recruitment and infiltration of immune cells, ...[more]
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