Ontology highlight
ABSTRACT:
SUBMITTER: Ottavi S
PROVIDER: S-EPMC8842310 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Ottavi Samantha S Scarry Sarah M SM Mosior John J Ling Yan Y Roberts Julia J Singh Amrita A Zhang David D Goullieux Laurent L Roubert Christine C Bacqué Eric E Lagiakos H Rachel HR Vendome Jeremie J Moraca Francesca F Li Kelin K Perkowski Andrew J AJ Ramesh Remya R Bowler Matthew M MM Tracy William W Feher Victoria A VA Sacchettini James C JC Gold Ben S BS Nathan Carl F CF Aubé Jeffrey J
Journal of medicinal chemistry 20220119 3
A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in <i>Mycobacterium tuberculosis</i>. The structure-activity relationships of a recently disclosed inhibitor, amidinourea (AU) 8918 (<b>1</b>), were explored, focusing on the biochemical potency, determination of whole-cell on-target activity for active compounds, and profiling of selective active conge ...[more]