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Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer.

ABSTRACT: Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors. As a consequence, thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice. This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

SUBMITTER: Ruan L

PROVIDER: S-EPMC8844157 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer.

Ruan Lifo L Chen Jun J Du Chuanchao C Lu Huiru H Zhang Jiayu J Cai Xiaomeng X Dou Rui R Lin Wenchu W Chai Zhifang Z Nie Guangjun G Hu Yi Y

Bioactive materials 20211104

Reversal of cancer drug resistance remains a critical challenge in chemotherapy. Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer. To overcome the intrinsic limitations in conventional mitochondrial targeting strategies, we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin (DOX) resistance in lung cancer. Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and ...[more]

PMID: 35224301

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