Ontology highlight
ABSTRACT:
SUBMITTER: Demmer JK
PROVIDER: S-EPMC8849298 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Demmer Julius K JK Phillips Ben P BP Uhrig O Lisa OL Filloux Alain A Allsopp Luke P LP Bublitz Maike M Meier Thomas T
Science advances 20220216 7
The global spread of multidrug-resistant <i>Acinetobacter baumannii</i> infections urgently calls for the identification of novel drug targets. We solved the electron cryo-microscopy structure of the F<sub>1</sub>F<sub>o</sub>-adenosine 5'-triphosphate (ATP) synthase from <i>A. baumannii</i> in three distinct conformational states. The nucleotide-converting F<sub>1</sub> subcomplex reveals a specific self-inhibition mechanism, which supports a unidirectional ratchet mechanism to avoid wasteful A ...[more]