Ontology highlight
ABSTRACT:
SUBMITTER: Qin X
PROVIDER: S-EPMC8854395 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Qin Xunsi X Zhao Yue Y Zhang Tianyi T Yin Chenghong C Qiao Jie J Guo Wei W Lu Bai B
Nature communications 20220217 1
Premature ovarian failure (POF) is a leading cause of women's infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody for the BDNF receptor TrkB, penetrates into ovarian follicles, activates TrkB signaling, and promotes ovary development. In both natural aging and cyclophosphamide-induced POF models, treatment with Ab4B19 completely reverses the reduction of pre-antral and antral follicles, and normalizes gonadal hormone. Ab4B19 also atte ...[more]