Ontology highlight
ABSTRACT:
SUBMITTER: Persico G
PROVIDER: S-EPMC8870338 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Persico Giuseppe G Casciaro Francesca F Amatori Stefano S Rusin Martina M Cantatore Francesco F Perna Amalia A Auber Lavinia Alberi LA Fanelli Mirco M Giorgio Marco M
Cells 20220219 4
<h4>Background</h4>Epigenetic remodeling is emerging as a critical process for both the onset and progression of Alzheimer's disease (AD), the most common form of neurodegenerative dementia. However, it is not clear to what extent the distribution of histone modifications is involved in AD.<h4>Methods</h4>To investigate histone H3 modifications in AD, we compared the genome-wide distributions of H3K4me3 and H3K27me3 in entorhinal cortices from severe sporadic AD patients and from age-matched hea ...[more]