Ontology highlight
ABSTRACT:
SUBMITTER: Lauriola A
PROVIDER: S-EPMC8878929 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Lauriola Angela A Uliassi Elisa E Santucci Matteo M Bolognesi Maria Laura ML Mor Marco M Scalvini Laura L Elisi Gian Marco GM Gozzi Gaia G Tagliazucchi Lorenzo L Marverti Gaetano G Ferrari Stefania S Losi Lorena L D'Arca Domenico D Costi Maria Paola MP
Pharmaceutics 20220210 2
The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in the Hippo pathway and are involved in cancer progression through modulation of the activity of TEAD (transcriptional enhanced associate domain) transcription factors. To exploit the advantages of drug repurposing in the search of new drugs, we developed a similar approach for the identification of new hits interfering with TEAD target gen ...[more]