Ontology highlight
ABSTRACT:
SUBMITTER: Zuo ZY
PROVIDER: S-EPMC8887470 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Zuo Zhen-Yu ZY Yang Guang-Hui GH Wang Hai-Yu HY Liu Shu-Yu SY Zhang Yan-Jun YJ Cai Yun Y Chen Fei F Dai Hui H Xiao Yi Y Cheng Mo-Bin MB Huang Yue Y Zhang Ye Y
Nucleic acids research 20220201 4
The second cell fate decision in the early stage of mammalian embryonic development is pivotal; however, the underlying molecular mechanism is largely unexplored. Here, we report that Prmt1 acts as an important regulator in primitive endoderm (PrE) formation. First, Prmt1 depletion promotes PrE gene expression in mouse embryonic stem cells (ESCs). Single-cell RNA sequencing and flow cytometry assays demonstrated that Prmt1 depletion in mESCs contributes to an emerging cluster, where PrE genes ar ...[more]