Ontology highlight
ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC8894417 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Lee Miyoung M Hamilton Jamie A G JAG Talekar Ganesh R GR Ross Anthony J AJ Michael Langston L Rupji Manali M Dwivedi Bhakti B Raikar Sunil S SS Boss Jeremy J Scharer Christopher D CD Graham Douglas K DK DeRyckere Deborah D Porter Christopher C CC Henry Curtis J CJ
Nature communications 20220303 1
The incidence of obesity is rising with greater than 40% of the world's population expected to be overweight or suffering from obesity by 2030. This is alarming because obesity increases mortality rates in patients with various cancer subtypes including leukemia. The survival differences between lean patients and patients with obesity are largely attributed to altered drug pharmacokinetics in patients receiving chemotherapy; whereas, the direct impact of an adipocyte-enriched microenvironment on ...[more]