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Organocatalytic asymmetric nitroso aldol reaction of α-substituted malonamates.

ABSTRACT: A practical enantioselective N-selective nitroso aldol reaction of α-methylmalonamates with a nitrosoarene is reported. The reaction employs the Takemoto thiourea catalyst for the induction of enantioselectivity, and the corresponding optically active oxyaminated malonamates were obtained in reasonably good yields.

SUBMITTER: Gupta E

PROVIDER: S-EPMC8895028 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Organocatalytic asymmetric nitroso aldol reaction of α<i>-</i>substituted malonamates.

Gupta Ekta E Vaishanv Narendra Kumar NK Kumar Sandeep S Purshottam Raja Krishnan RK Kant Ruchir R Mohanan Kishor K

Beilstein journal of organic chemistry 20220221

A practical enantioselective N-selective nitroso aldol reaction of α-methylmalonamates with a nitrosoarene is reported. The reaction employs the Takemoto thiourea catalyst for the induction of enantioselectivity, and the corresponding optically active oxyaminated malonamates were obtained in reasonably good yields. ...[more]

PMID: 35280951

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