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Association of severity and mortality of Covid-19 cases among acute kidney injury and sexual dimorphism.


ABSTRACT:

Introduction

The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.

Material and methods

The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates the viral genome protein interactions and initiates the predictive multiorgan failure followed by acute kidney injury (AKI) in Covid-19 infected male population.

Conclusion

Besides, the knowledge and lessons learned from the study depict that cellular and molecular links may explain the risk and severity of Covid-19 and AKI in the male population and lead to management of Covid-19 induced AKI. Therefore, this review explored the pathways associated with the pathogenesis of two diseased conditions with sex disparity.

SUBMITTER: Singh MK 

PROVIDER: S-EPMC8898193 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Association of severity and mortality of Covid-19 cases among acute kidney injury and sexual dimorphism.

Singh Mukul Kumar MK   Jain Mayank M   Shyam Hari H   Sahu Dinesh Kumar DK   Mishra Archana A   Shankar Pratap P   Kumar Shailendra S   Singh Vishwajeet V  

Molecular biology reports 20220306 7


<h4>Introduction</h4>The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.<h4>Material and methods</h4>The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates  ...[more]

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