Ontology highlight
ABSTRACT: Introduction
The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.Material and methods
The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates the viral genome protein interactions and initiates the predictive multiorgan failure followed by acute kidney injury (AKI) in Covid-19 infected male population.Conclusion
Besides, the knowledge and lessons learned from the study depict that cellular and molecular links may explain the risk and severity of Covid-19 and AKI in the male population and lead to management of Covid-19 induced AKI. Therefore, this review explored the pathways associated with the pathogenesis of two diseased conditions with sex disparity.
SUBMITTER: Singh MK
PROVIDER: S-EPMC8898193 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Singh Mukul Kumar MK Jain Mayank M Shyam Hari H Sahu Dinesh Kumar DK Mishra Archana A Shankar Pratap P Kumar Shailendra S Singh Vishwajeet V
Molecular biology reports 20220306 7
<h4>Introduction</h4>The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.<h4>Material and methods</h4>The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates ...[more]