Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC8898372 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Liu Fei F Han Qianying Q Zhang Ting T Chang Fen F Deng Jingcheng J Huang Xiaotian X Wang Weiping W Xu Yongjie Y Li Qin Q Xu Luzheng L Zhang Bo B Li Wentong W Li Li L Su Yanrong Y Li Yang Y Shao Genze G
International journal of biological sciences 20220124 4
BRCA1 is frequently down-regulated in breast cancer, the underlying mechanism is unclear. Here we identified DCAF8L1, an X-linked gene product, as a DDB1-Cullin associated Factor (DCAF) for CUL4 E3 ligases to target BRCA1 and BARD1 for proteasomal degradation. Forced expression of DCAF8L1 caused reduction of BRCA1 and BARD1, and impaired DNA damage repair function, conferring increased sensitivity to irradiation and DNA damaging agents, as well as Olaparib, a PARPi anticancer drug; while depleti ...[more]