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Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel.

ABSTRACT: Bacterial infections still cause many health problems for human beings. Silica aerogels with a three-dimensional (3D) porous structure and a large surficial area are promising candidates for drug delivery, but they have rarely been investigated for antibacterial agent delivery. Herein, we study mesoporous silica aerogels as carriers for delivery of three slightly soluble antibacterial agents including cinnamaldehyde (CA, liquid), salicylic acid (SAA, solid), and sorbic acid (SOA, solid) under supercritical fluid carbon dioxide. Notably, all three antibacterial agents form uniform nanocrystals in the mesopores of silica aerogels and the loading efficiency reaches 56 wt %, which assists in overcoming the obstacles of low bioavailability of slightly soluble antibacterial agents. Benefiting from nanocrystallized antibacterial agents, the agent-loaded aerogels exhibit an inhibition rate of 99.99% against Escherichia coli during the initial release; notably, they still have a 95% inhibition rate even after ∼90% of CA is released. Importantly, the agent-loaded silica aerogels demonstrate good biocompatibility in vitro. This work indicates that mesoporous silica aerogels are a promising platform for antibacterial agent delivery.

SUBMITTER: Xie H

PROVIDER: S-EPMC8908532 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel.

Xie Hui H He Zhiguo Z Liu Yanxing Y Zhao Changbo C Guo Bing B Zhu Caizhen C Xu Jian J

ACS omega 20220225 9

Bacterial infections still cause many health problems for human beings. Silica aerogels with a three-dimensional (3D) porous structure and a large surficial area are promising candidates for drug delivery, but they have rarely been investigated for antibacterial agent delivery. Herein, we study mesoporous silica aerogels as carriers for delivery of three slightly soluble antibacterial agents including cinnamaldehyde (CA, liquid), salicylic acid (SAA, solid), and sorbic acid (SOA, solid) under su ...[more]

PMID: 35284760

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Project description:BackgroundImproving anti-cancer drug delivery performance can be achieved through designing smart and targeted drug delivery systems (DDSs). For this aim, it is important to evaluate overexpressed biomarkers in the tumor microenvironment (TME) for optimizing DDSs.Materials and methodsHerein, we designed a novel DDS based on magnetic mesoporous silica core-shell nanoparticles (SPION@MSNs) in which release of doxorubicin (DOX) at the physiologic pH was blocked with gold gatekeepers. In this platform, we conjugated heterofunctional polyethylene glycol (PEG) onto the outer surface of nanocarriers to increase their biocompatibility. At the final stage, an epithelial cell adhesion molecule (EpCAM) aptamer as an active targeting moiety was covalently attached (Apt-PEG-Au@NPs-DOX) for selective drug delivery to colorectal cancer (CRC) cells. The physicochemical properties of non-targeted and targeted nanocarriers were fully characterized. The anti-cancer activity, cellular internalization, and then the cell death mechanism of prepared nanocarriers were determined and compared in vitro. Finally, tumor inhibitory effects, biodistribution and possible side effects of the nanocarriers were evaluated in immunocompromised C57BL/6 mice bearing human HT-29 tumors.ResultsNanocarriers were successfully synthesized with a mean final size diameter of 58.22 ± 8.54 nm. Higher cytotoxicity and cellular uptake of targeted nanocarriers were shown in the EpCAM-positive HT-29 cells as compared to the EpCAM-negative CHO cells, indicating the efficacy of aptamer as a targeting agent. In vivo results in a humanized mouse model showed that targeted nanocarriers could effectively increase DOX accumulation in the tumor site, inhibit tumor growth, and reduce the adverse side effects.ConclusionThese results suggest that corporation of a magnetic core, gold gatekeeper, PEG and aptamer can strongly improve drug delivery performance and provide a theranostic DDS for efficient CRC therapy.

Dataset Information

Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel.

Publications

Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel.

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