Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer.
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ABSTRACT:
SUBMITTER: Lorenzin F
PROVIDER: S-EPMC8909394 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Past, Current, and Future Strategies to Target ERG Fusion-Positive Prostate Cancer.
Lorenzin Francesca F Demichelis Francesca F
Cancers 20220222 5
The ETS family member ERG is a transcription factor with physiological roles during development and in the vascular and hematopoietic systems. ERG oncogenic activity characterizes several malignancies, including Ewing's sarcoma, leukemia and prostate cancer (PCa). In PCa, <i>ERG</i> rearrangements with androgen-regulated genes-mostly <i>TMPRSS2</i>-characterize a large subset of patients across disease progression and result in androgen receptor (AR)-mediated overexpression of ERG in the prostat ...[more]
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