Ontology highlight
ABSTRACT:
SUBMITTER: Giraudi PJ
PROVIDER: S-EPMC8911336 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Giraudi Pablo J PJ Salvoza Noel N Bonazza Deborah D Saitta Carlo C Lombardo Daniele D Casagranda Biagio B de Manzini Nicolò N Pollicino Teresa T Raimondo Giovanni G Tiribelli Claudio C Palmisano Silvia S Rosso Natalia N
International journal of molecular sciences 20220304 5
Fibrosis is the strongest predictor for disease-specific mortality in non-alcoholic fatty liver diseases (NAFLD), but the need for liver biopsy limits its diagnosis. We assessed the performance of plasma ficolin-2 (FCN-2) as a biomarker of fibrosis identified by an in silico discovery strategy. Two hundred and thirty-five morbidly obese (MO) subjects with biopsy-proven NAFLD stratified by fibrosis stage (F0, n = 44; F1, n = 134; F2, n = 46; F3/F4, n = 11) and 40 cirrhotic patients were enrolled. ...[more]