Ontology highlight
ABSTRACT:
SUBMITTER: Cardenas A
PROVIDER: S-EPMC8917214 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Cardenas Andres A Ecker Simone S Fadadu Raj P RP Huen Karen K Orozco Allan A McEwen Lisa M LM Engelbrecht Hannah-Ruth HR Gladish Nicole N Kobor Michael S MS Rosero-Bixby Luis L Dow William H WH Rehkopf David H DH
Scientific reports 20220311 1
Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated smoking-associated DNAm signatures in the Costa Rican Study on Longevity and Healthy Aging (CRELES), including participants from the high longevity region of Nicoya. We measured genome-wide DNAm in leukocytes, tested Epigenetic Age Acceleration (EAA) from five clocks and estimate ...[more]