Ontology highlight
ABSTRACT:
SUBMITTER: McMurry LM
PROVIDER: S-EPMC89191 | biostudies-literature | 1999 Mar
REPOSITORIES: biostudies-literature
McMurry L M LM McDermott P F PF Levy S B SB
Antimicrobial agents and chemotherapy 19990301 3
Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid resistance. A mutation originally selected on isoniazid also mediated triclosan resistance, as did the wild-type inhA gene on a multicopy plasmid. Replacement of the mutant chromosomal inhA genes with wild-type inhA eliminated resistance. These results suggest that M. smegmatis InhA, like its Escherichi ...[more]