Unknown

Dataset Information

0

Alterations in GyrA and ParC associated with fluoroquinolone resistance in Enterococcus faecium.

ABSTRACT: High-level quinolone resistance in Enterococcus faecium was associated with mutations in both gyrA and parC genes in 10 of 11 resistant strains. On low-level resistant strain without such mutations may instead possess an efflux mechanism or alterations in the other subunits of the gyrase or topoisomerase IV genes. These findings are similar to those for other gram-positive bacteria, such as Enterococcus faecalis.

SUBMITTER: el Amin NA 

PROVIDER: S-EPMC89232 | biostudies-literature | 1999 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Alterations in GyrA and ParC associated with fluoroquinolone resistance in Enterococcus faecium.

el Amin N A NA   Jalal S S   Wretlind B B  

Antimicrobial agents and chemotherapy 19990401 4

High-level quinolone resistance in Enterococcus faecium was associated with mutations in both gyrA and parC genes in 10 of 11 resistant strains. On low-level resistant strain without such mutations may instead possess an efflux mechanism or alterations in the other subunits of the gyrase or topoisomerase IV genes. These findings are similar to those for other gram-positive bacteria, such as Enterococcus faecalis. ...[more]

Similar Datasets

Unknown Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.
| S-EPMC89510 | biostudies-literature
Unknown High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.
| S-EPMC1393140 | biostudies-literature
Unknown Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumannii.
| S-EPMC3767088 | biostudies-literature
Unknown Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
| S-EPMC105429 | biostudies-literature
Unknown Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
| S-EPMC162795 | biostudies-other
Unknown gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Kenya.
| S-EPMC6454682 | biostudies-literature
Unknown Fluoroquinolone resistance mutations in the parC, parE, and gyrA genes of clinical isolates of viridans group streptococci.
| S-EPMC105945 | biostudies-literature
Unknown Resistance Mutations in gyrA and parC are Common in Escherichia Communities of both Fluoroquinolone-Polluted and Uncontaminated Aquatic Environments.
| S-EPMC4673309 | biostudies-literature
Unknown Horizontal transfer of parC and gyrA in fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.
| S-EPMC89780 | biostudies-literature
Unknown gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
| S-EPMC105915 | biostudies-literature