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Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.

ABSTRACT: The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in combination with other resistance mechanisms, severely restricted the in vitro activities of the nine quinolones tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities.

SUBMITTER: Brisse S 

PROVIDER: S-EPMC89510 | biostudies-literature | 1999 Oct

REPOSITORIES: biostudies-literature

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Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.

Brisse S S   Fluit A C AC   Wagner U U   Heisig P P   Milatovic D D   Verhoef J J   Scheuring S S   Köhrer K K   Schmitz F J FJ  

Antimicrobial agents and chemotherapy 19991001 10

The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in combination with other resistance mechanisms, severely restricted the in vitro activities of the nine quinolones tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities. ...[more]

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