Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
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ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC8931372 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
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Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
Zhang Shuai S Nelson Ornella D OD Price Ian R IR Zhu Chengliang C Lu Xuan X Fernandez Irma R IR Weiss Robert S RS Lin Hening H
Proceedings of the National Academy of Sciences of the United States of America 20220308 11
SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites. ...[more]
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