Ontology highlight
ABSTRACT:
SUBMITTER: Ripperger JA
PROVIDER: S-EPMC8946863 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Ripperger Jürgen A JA Chavan Rohit R Albrecht Urs U Brenna Andrea A
Clocks & sleep 20220309 1
Circadian rhythms are self-sustained oscillators with a period of 24 h that is based on the output of transcriptional and post-translational feedback loops. Phosphorylation is considered one of the most important post-translational modifications affecting rhythmicity from cyanobacteria to mammals. For example, the lack of cyclin-dependent kinase 5 (CDK5) shortened the period length of the circadian oscillator in the Suprachiasmatic Nuclei (SCN) of mice via the destabilization of the PERIOD 2 (PE ...[more]