Ontology highlight
ABSTRACT:
SUBMITTER: Fenteany G
PROVIDER: S-EPMC8958325 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
iScience 20220310 4
Ubiquitination of proliferating cell nuclear antigen (PCNA) triggers pathways of DNA damage tolerance, including mutagenic translesion DNA synthesis, and comprises a cascade of reactions involving the E1 ubiquitin-activating enzyme Uba1, the E2 ubiquitin-conjugating enzyme Rad6, and the E3 ubiquitin ligase Rad18. We report here the discovery of a series of xanthenes that inhibit PCNA ubiquitination, Rad6∼ubiquitin thioester formation, and the Rad6-Rad18 interaction. Structure-activity relationsh ...[more]