Ontology highlight
ABSTRACT:
SUBMITTER: Adachi Y
PROVIDER: S-EPMC8960774 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Adachi Yuichiro Y Masuda Masashi M Sakakibara Iori I Uchida Takayuki T Niida Yuki Y Mori Yuki Y Kamei Yuki Y Okumura Yosuke Y Ohminami Hirokazu H Ohnishi Kohta K Yamanaka-Okumura Hisami H Nikawa Takeshi T Taketani Yutaka Y
Life science alliance 20220322 7
All-trans retinoic acid (ATRA) increases the sensitivity to unfolded protein response in differentiating leukemic blasts. The downstream transcriptional factor of PERK, a major arm of unfolded protein response, regulates muscle differentiation. However, the role of growth arrest and DNA damage-inducible protein 34 (GADD34), one of the downstream factors of PERK, and the effects of ATRA on GADD34 expression in muscle remain unclear. In this study, we identified ATRA increased the GADD34 expressio ...[more]