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Controlled Intracellular Polymerization for Cancer Treatment.

ABSTRACT: Numerous prodrugs have been developed and used for cancer treatments to reduce side effects and promote efficacy. In this work, we have developed a new photoactivatable prodrug system based on intracellular photoinduced electron transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization. This unique polymerization process provided a platform for the synthesis of structure-predictable polymers with well-defined structures in living cells. The intracellularly generated poly(N,N-dimethylacrylamide)s were found to induce cell cycle arrest, apoptosis, and necroptosis, inhibit cell proliferation, and reduce cancer cell motilities. This polymerization-based "prodrug" system efficiently inhibits tumor growth and metastasis both in vitro and in vivo and will promote the development of targeted and directed cancer chemotherapy.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC8970002 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Controlled Intracellular Polymerization for Cancer Treatment.

Zhang Yichuan Y Gao Quan Q Li Weishuo W He Rongkun R Zhu Liwei L Lian Qianjin Q Wang Liang L Li Yang Y Bradley Mark M Geng Jin J

JACS Au 20220223 3

Numerous prodrugs have been developed and used for cancer treatments to reduce side effects and promote efficacy. In this work, we have developed a new photoactivatable prodrug system based on intracellular photoinduced electron transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization. This unique polymerization process provided a platform for the synthesis of structure-predictable polymers with well-defined structures in living cells. The intracellularly generated pol ...[more]

PMID: 35373203

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