Unknown

Dataset Information

0

Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020.


ABSTRACT: The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and to reconstruct the origin and the evolutionary dynamics in Italy and Europe between February and June 2020. The cluster analysis showed only small clusters including < 80 Italian isolates, while most of the Italian strains were intermixed in the whole tree. Pure Italian clusters were observed mainly after the lockdown and distancing measures were adopted. Lineage B and B.1 spread between late January and early February 2020, from China to Veneto and Lombardy, respectively. Lineage B.1.1 (20B) most probably evolved within Italy and spread from central to south Italian regions, and to European countries. The lineage B.1.1.1 (20D) developed most probably in other European countries entering Italy only in the second half of March and remained localized in Piedmont until June 2020. In conclusion, within the limitations of phylogeographical reconstruction, the estimated ancestral scenario suggests an important role of China and Italy in the widespread diffusion of the D614G variant in Europe in the early phase of the pandemic and more dispersed exchanges involving several European countries from the second half of March 2020.

SUBMITTER: Lai A 

PROVIDER: S-EPMC8986836 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020.

Lai Alessia A   Bergna Annalisa A   Toppo Stefano S   Morganti Marina M   Menzo Stefano S   Ghisetti Valeria V   Bruzzone Bianca B   Codeluppi Mauro M   Fiore Vito V   Rullo Emmanuele Venanzi EV   Antonelli Guido G   Sarmati Loredana L   Brindicci Gaetano G   Callegaro Annapaola A   Sagnelli Caterina C   Francisci Daniela D   Vicenti Ilaria I   Miola Arianna A   Tonon Giovanni G   Cirillo Daniela D   Menozzi Ilaria I   Caucci Sara S   Cerutti Francesco F   Orsi Andrea A   Schiavo Roberta R   Babudieri Sergio S   Nunnari Giuseppe G   Mastroianni Claudio M CM   Andreoni Massimo M   Monno Laura L   Guarneri Davide D   Coppola Nicola N   Crisanti Andrea A   Galli Massimo M   Zehender Gianguglielmo G  

Scientific reports 20220406 1


The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and to reconstruct the origin and the evolutionary dynamics in Italy and Europe between February and June 2020. The cluster analysis showed only small clusters including < 80 Italian isolates, while most of the Italian strains were intermixed in the whole tree. Pure Italian clusters were observed mainly after the lockdown and distancing measures were adopted. Lineage B and B.1 spread between late January an  ...[more]

Similar Datasets

| S-EPMC8053246 | biostudies-literature
| S-EPMC7873460 | biostudies-literature
| S-EPMC7392408 | biostudies-literature
| S-EPMC8249441 | biostudies-literature
| S-EPMC7295299 | biostudies-literature
| S-EPMC9838690 | biostudies-literature
| S-EPMC7588545 | biostudies-literature
| S-EPMC8473193 | biostudies-literature
| S-EPMC10204622 | biostudies-literature
| S-EPMC6060430 | biostudies-literature