Ontology highlight
ABSTRACT:
SUBMITTER: Whetstone CE
PROVIDER: S-EPMC8997824 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Whetstone Christiane E CE Ranjbar Maral M Omer Hafsa H Cusack Ruth P RP Gauvreau Gail M GM
Cells 20220324 7
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors triggers the release of alarmin cytokines IL-25, IL-33, and TSLP. These alarmins are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells. Many of the key effector cells in the allergic ca ...[more]