The Role of Airway Epithelial Cell Alarmins in Asthma.
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ABSTRACT:
SUBMITTER: Whetstone CE
PROVIDER: S-EPMC8997824 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
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The Role of Airway Epithelial Cell Alarmins in Asthma.
Whetstone Christiane E CE Ranjbar Maral M Omer Hafsa H Cusack Ruth P RP Gauvreau Gail M GM
Cells 20220324 7
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors triggers the release of alarmin cytokines IL-25, IL-33, and TSLP. These alarmins are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells. Many of the key effector cells in the allergic ca ...[more]
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Project description:We performed genome-wide profiling of miRNA expression in the airway epithelial compartment in asthma to identify miRNA pathways associated with epithelial abnormalities using miRNA microarrays and real-time PCR. We also sought to identify the effect of inhaled corticosteroids (ICS) on airway epithelial miRNA expression Samples were obtained from airway epithelial cells by bronchoscopic brushing from three groups of subjects: Healthy Controls ( N=12), Steroid Naïve Asthma (N=16), Steroid-requiring Asthma (N=19).
2012-12-05 | E-GEOD-34466 | biostudies-arrayexpress
Project description:We performed genome-wide profiling of miRNA expression in the airway epithelial compartment in asthma to identify miRNA pathways associated with epithelial abnormalities using miRNA microarrays and real-time PCR. We also sought to identify the effect of inhaled corticosteroids (ICS) on airway epithelial miRNA expression
2012-12-05 | GSE34466 | GEO